Name | metaraminol bitartrate |
Synonyms | Bitartrate pressonexbitartrate metraminolbitartrate metaraminol bitartrate Metaraminal bitartrate Aramine (sympathomimetic) metaraminol hydrogen (+)-tartrate (-)-M-HYDROXYPHENYLPROPANOLAMINE BITARTRATE SALT (-)-alpha-(1-aminoethyl)-m-hydroxybenzylalcoholbitartrate 3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol 2,3-dihydroxybutanedioate (salt) |
CAS | 33402-03-8 |
EINECS | 251-502-3 |
InChI | InChI=1/C9H13NO2.C4H6O6/c1-6(10)9(12)7-3-2-4-8(11)5-7;5-1(3(7)8)2(6)4(9)10/h2-6,9,11-12H,10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t6-,9-;/m0./s1 |
InChIKey | VENXSELNXQXCNT-IJYXXVHRSA-N |
Molecular Formula | C13H19NO8 |
Molar Mass | 317.29 |
Melting Point | 176-177° |
Boling Point | 357.9°C at 760 mmHg |
Flash Point | 170.3°C |
Vapor Presure | 9.58E-06mmHg at 25°C |
Storage Condition | Room Temprature |
Hazard Symbols | T - Toxic |
Risk Codes | 23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | DN5160000 |
HS Code | 2939800000 |
This product is (mono-aminoethyl)-3-hydroxybenzyl alcohol bitartrate. Calculated on a dry basis, the content of C9H13N02 • C4H606 shall not be less than 98.5%.
The melting point of this product is 171~176°C (General 0612).
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.152 ml | 15.758 ml | 31.517 ml |
5 mM | 0.63 ml | 3.152 ml | 6.303 ml |
10 mM | 0.315 ml | 1.576 ml | 3.152 ml |
5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
take L. 0g of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 3.2~3.5.
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 0.4mg per lml as a test solution; Take an appropriate amount for precision measurement, A solution containing about 1 ug per 1 ml was prepared as a control solution by quantitative dilution with water. Tested according to high performance liquid chromatography (General 0512). Silica gel was bonded with eighteen alkyl silane as filler; 0.03% sodium hexane sulfonate solution (adjusted to pH 40% with 3.0 phosphoric acid)-methanol (80:20) as mobile phase; The detection wavelength was 220nm. The number of theoretical plates shall not be less than 5000 calculated by the peak of meta-hydroxylamine, and the separation degree between the peak of meta-hydroxylamine and the adjacent impurity peaks shall meet the requirements. 20 u1 of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks (except tartaric acid peaks) in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.25% ) , the sum of each impurity peak area shall not be greater than 4 times (1.0%) of the main peak area of the control solution.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
not more than 0.1% (General rule 0841).
take this product about 0. LG, precision weighing, put in iodine bottle, water 40ml to dissolve, precision plus bromine titration solution (0.05mol/L) 40ml, plus hydrochloric acid 8ml, immediately close the plug, place it for 15 minutes, pay attention to opening the stopper, add 8ml of potassium iodide solution, immediately close the plug, shake, rinse the stopper and bottleneck of the iodine bottle with a small amount of water, add 1 ml of chloroform, shake, with sodium thiosulfate titration solution (0.1 mol/L) titration, to the near end point, add starch indicator solution, continue titration to blue disappeared, and the titration result is corrected by blank test. Each 1 ml of bromine titration solution (0.05mol/L) corresponds to 5.288mg of C9H13N02. C4H606.
a adrenoceptor agonists.
light shielding, sealed storage.
This product is a sterilized aqueous solution of M-hydroxylamine bitartrate. M-hydroxylamine (C9H13N02) shall be between 93.0% and 107.0% of the label amount.
This product is a clear colorless liquid.
take 1 ml of this product, add 2 drops of sodium nitroprusside test solution, 2 drops of acetone and 0.2g of sodium bicarbonate, and heat it in a water bath at 60 ° C. For 1 minute to show red and purple color.
take 5ml of this product accurately (about 50mg equivalent to M-hydroxylamine), put it in a 50ml measuring flask, dilute it with water to the scale, shake well; Take 5ml accurately and put it in a 100ml measuring flask, dilute to the scale with water, shake well, and measure the absorbance at the wavelength of 272mn by UV-visible spectrophotometry (General rule 0401), and calculate the absorption coefficient of C9H13NO2 as 111.
Same as M-hydroxylamine bitartrate.
by C9H13N02 (l)lml:1Omg(2)5ml:50Mg
light shielding, closed storage.
introduction | metartaric acid hydroxylamine is white crystalline powder; odorless and bitter. |
use | metartaric acid hydroxylamine is a white crystalline powder, which can be used for bleeding, drug allergy, surgical complications and brain trauma or brain tumor The adjuvant symptomatic treatment of hypotension caused by shock can also be used to treat hypotension caused by cardiogenic shock or sepsis. |
contraindications | 1. those who are allergic to this drug are prohibited. 2. Those who use chloroform, halothane and cyclopropane for general anesthesia are prohibited. Those who have used monoamine oxidase to suppress drugs within 3.2 weeks are prohibited. |